Lidocaine Induces Endoplasmic Reticulum Stress-Associated Apoptosis in Vitro and in Vivo

@inproceedings{Hong2011LidocaineIE,
  title={Lidocaine Induces Endoplasmic Reticulum Stress-Associated Apoptosis in Vitro and in Vivo},
  author={Dae Young Hong and Kisang Kwon and Kyeong Ryong Lee and Young Jin Choi and Tae-Won Goo and Kweon Yu and Seung-whan Kim and O. -Yu Kwon},
  booktitle={International journal of molecular sciences},
  year={2011}
}
We demonstrated that upregulation of both gene expression of endoplasmic reticulum (ER) stress chaperones (BiP, calnexin, calreticulin, and PDI) and ER stress sensors (ATF6, IRE1 and PERK) was induced by lidocaine, a local anesthetic, in PC12 cells. In addition to gene regulation, lidocaine also induced typical ER stress phenomena such as ART6 proteolytic cleavage, eIF2 alpha phosphorylation, and XBP1 mRNA splicing. In in vivo experiments, while lidocaine downregulated gene expression of… CONTINUE READING
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