Licorice inhibits corticosteroid 11 beta-dehydrogenase of rat kidney and liver: in vivo and in vitro studies.

@article{Monder1989LicoriceIC,
  title={Licorice inhibits corticosteroid 11 beta-dehydrogenase of rat kidney and liver: in vivo and in vitro studies.},
  author={C See Monder and P. M. Stewart and Vijaya Lakshmi and Rossella Valentino and Davina Burt and Christopher R. W. Edwards},
  journal={Endocrinology},
  year={1989},
  volume={125 2},
  pages={1046-53}
}
In humans, glycyrrhetinic acid (GE), the active pharmacological ingredient of licorice, produces symptoms resembling those caused by excess mineralocorticoid secretion. We are proposing that 11 beta-dehydrogenase inhibition, and not intrinsic mineralocorticoid activity, is the primary mechanism of licorice induced pseudoaldosteronism. Glycyrrhizic acid… CONTINUE READING