Licochalcone E present in licorice suppresses lung metastasis in the 4T1 mammary orthotopic cancer model.

  title={Licochalcone E present in licorice suppresses lung metastasis in the 4T1 mammary orthotopic cancer model.},
  author={Soo Jin Kwon and So Young Park and Gyoo Taik Kwon and Ki Won Lee and Young-Hee Kang and Myung-Sook Choi and Jong Won Yun and Jae-Ho Jeon and Jong Gab Jun and Jung Han Yoon Park},
  journal={Cancer prevention research},
  volume={6 6},
We investigated whether licochalcone E (LicE), a phenolic constituent of licorice, inhibits mammary tumor growth and metastasis using animal and cell culture models. 4T1 mammary carcinoma cells were injected into the mammary fat pads of syngeneic BALB/c mice. Starting 7 days after the injection, the mice received LicE (7 or 14 mg/kg body weight/day) via oral gavage for 25 days. LicE suppressed solid tumor growth and lung metastasis, but did not exhibit kidney or liver toxicity. In tumor tissues… CONTINUE READING
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