Licochalcone E activates Nrf2/antioxidant response element signaling pathway in both neuronal and microglial cells: therapeutic relevance to neurodegenerative disease.

@article{Kim2012LicochalconeEA,
  title={Licochalcone E activates Nrf2/antioxidant response element signaling pathway in both neuronal and microglial cells: therapeutic relevance to neurodegenerative disease.},
  author={Sa Suk Kim and Juhee Lim and Yeojin Bang and Jiyeong Gal and Sang-Uk Lee and Young-Chang Cho and Goo Yoon and Bok Yun Kang and Seung Hoon Cheon and Hyun Jin Choi},
  journal={The Journal of nutritional biochemistry},
  year={2012},
  volume={23 10},
  pages={1314-23}
}
Oxidative stress and neuroinflammation are hallmarks of neurodegenerative diseases, which do not play independently but work synergistically through complex interactions exacerbating neurodegeneration. Therefore, the mechanism that is directly implicated in controlling oxidative stress and inflammatory response could be an attractive strategy to prevent the onset and/or delay the progression of neurodegenerative diseases. The transcription factor nuclear factor-E2-related factor-2 (Nrf2) is the… CONTINUE READING