Lichen sclerosus et atrophicus and autoimmunity—a study of 350 women

@article{Thomas1988LichenSE,
  title={Lichen sclerosus et atrophicus and autoimmunity—a study of 350 women},
  author={R.H. MEYRICK Thomas and C. M. Ridley and David Mcgibbon and Martin M. Black},
  journal={British Journal of Dermatology},
  year={1988},
  volume={118}
}
A study of autoimmune related phenomena in 350 women with histologically confirmed lichen sclerosus et atrophicus revealed that 21.5% had one or more autoimmune related diseases, 21% had one or more first degree relatives with an autoimmune‐related disease, 42% had an autoantibody at a titre > 1:20, and 59.5% had one or more of these autoimmune‐relateda phenomena. No statistically significant differences in the natural history of lichen sclerosus et atrophicus were demonstrated between those… Expand
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Patients with lichen sclerosus et atrophicus had a significantly higher incidence of autoimmune‐related disorders than a control population and a higher occurrence of autoantibodies than would be expected in the normal male population. Expand
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The data supports the belief that there is an association between lichen sclerosus et atrophicus and autoimmune disease in men. Expand
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None of the sera from patients with lichen sclerosus contained antibodies to steroid-producing tissues, and the findings suggest that the disease may be related to an autoimmune process. Expand
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TLDR
A study of the HLA-A, B and DR antigens and properdin factor B allotypes of 26 patients with lichen sclerosus et atrophicus and a normal control population shows an increase in the Hla-Aw31 antigen only, which suggests an association between lichens sclerOSus and the HLa system. Expand
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Itraconazole has proved to be a safe and effective drug for the treatment of chromomycosis; at present it seems to be the drug of choice. Expand
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