Lichen planopilaris is characterized by immune privilege collapse of the hair follicle's epithelial stem cell niche.

@article{Harries2013LichenPI,
  title={Lichen planopilaris is characterized by immune privilege collapse of the hair follicle's epithelial stem cell niche.},
  author={M Harries and Katja M. Meyer and Iskander H. Chaudhry and Jennifer E Kloepper and E Poblet and Christopher Griffiths and Ralf Paus},
  journal={The Journal of pathology},
  year={2013},
  volume={231 2},
  pages={236-47}
}
Lichen planopilaris (LPP) is a chronic inflammatory disease of unknown pathogenesis that leads to permanent hair loss. Whilst destruction of epithelial hair follicle stem cells (eHFSCs) that reside in an immunologically protected niche of the HF epithelium, the bulge, is a likely key event in LPP pathogenesis, this remains to be demonstrated. We have tested the hypotheses that bulge immune privilege (IP) collapse and inflammation-induced eHFSC death are key components in the pathogenesis of LPP… CONTINUE READING
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