Lichen metabolites prevent UV light and nitric oxide-mediated plasmid DNA damage and induce apoptosis in human melanoma cells.

@article{Russo2008LichenMP,
  title={Lichen metabolites prevent UV light and nitric oxide-mediated plasmid DNA damage and induce apoptosis in human melanoma cells.},
  author={Alessandra Russo and Marisa Piovano and Laura A. Lombardo and Juan Antonio Garbarino and Venera Cardile},
  journal={Life sciences},
  year={2008},
  volume={83 13-14},
  pages={
          468-74
        }
}
In humans both UV-A and UV-B can cause gene mutations and suppress immunity, which leads to skin cancer, including melanoma. Inhibition of reactive oxygen species (ROS) and reactive nitrogen species (RNS) appears particularly promising as ROS and RNS production by both UV-A and UV-B contributes to inflammation, immunosuppression, gene mutation and carcinogenesis. We evaluated the effect of two lichen compounds, sphaerophorin (depside) and pannarin (depsidone) on pBR322 DNA cleavage induced by… CONTINUE READING
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