Lichen Planopilaris and Frontal Fibrosing Alopecia as Model Epithelial Stem Cell Diseases.

@article{Harries2018LichenPA,
  title={Lichen Planopilaris and Frontal Fibrosing Alopecia as Model Epithelial Stem Cell Diseases.},
  author={M J Harries and Francisco Jimenez and Ander Izeta and Jonathan A Hardman and Sreejith Parameswara Panicker and E Poblet and Ralf Paus},
  journal={Trends in molecular medicine},
  year={2018},
  volume={24 5},
  pages={
          435-448
        }
}
Inflammation-associated, irreversible damage to epithelial stem cells (eSCs) of the hair follicle in their immunologically privileged niche lies at the heart of scarring alopecia, which causes permanent difficult-to-treat hair loss. We propose that the two most common and closely related forms, lichen planopilaris (LPP) and frontal fibrosing alopecia (FFA), provide excellent model diseases for studying the biology and pathology of adult human eSCs in an easily accessible human mini-organ… CONTINUE READING
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