Liberating the data from clinical trials

@article{Henry2015LiberatingTD,
  title={Liberating the data from clinical trials},
  author={David Henry and Tiffany Fitzpatrick},
  journal={BMJ : British Medical Journal},
  year={2015},
  volume={351}
}
Liberated trial data have enduring potential to benefit patients, prevent harm, and correct misleading research 
View on BMJ
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19 Citations
Background Citations
3

19 Citations

Benefits of, and barriers to, reactivating dormant trials
TLDR
The UK should follow Ontario and reactivate its treasure trove of dormant trials to generate new science through linkage with administrative data to monitor long term safety of drugs.
Data sharing is desirable, but benefits should not be exaggerated
On behalf of the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) research group, we thank Henry and Fitzpatrick for their praise of how…
Assessment of Long-term Follow-up of Randomized Trial Participants by Linkage to Routinely Collected Data
TLDR
The fate of patients after participation in clinical trials is a neglected topic, and the authors recommend that researchers routinely request permission from trial participants to study long-term treatment effects using linkage to routinely collected data.
Protocol for a scoping review of post-trial extensions of randomised controlled trials using individually linked administrative and registry data
TLDR
This scoping review aims to characterise published post-trial extension studies, assess their value, and identify any potential challenges associated with this approach, to produce guidance for investigators on the conduct of post- trial extensions using routinely collected data.
Inauguration of the Journal of Emergency and Critical Care Medicine
TLDR
Emergency and critical care medicine are specialties facing life-threatening emergencies such as stroke, acute myocardial infarction, and severe trauma and most practices in emergency room and intensive care unit (ICU) lack high-level evidence.
Antidepressants: Conundrums and Complexities of Efficacy Studies
  • R. Pies
  • Psychology
    Journal of clinical psychopharmacology
  • 2016
TLDR
Despite the apparent failure of Study 329, the preponderance of research still supports modest-to-moderate efficacy—and overall safety—for several commonly used antidepressants, and influential meta-analyses suggesting that the efficacy of antidepressants for major depression is exaggerated and/or limited to severe depression.
[Pharmacovigilance in Germany : It is about time].
TLDR
Without publicly funded large longitudinal healthcare databases and an amendment of Section 75, Book 10, of the Code of Social Law, the use of healthcare data in pharmacovigilance research in Germany will remain a rarity.
If you build it, they will come: unintended future uses of organised health data collections
TLDR
The main purpose of this paper is to raise awareness of the potential for unforeseen and unintended consequences of the increased availability and development of health data collections for research, by providing a comprehensive review of documented and hypothetical non-health research uses of such data.
Investing in Endovascular Thrombectomy Programs: Saving Lives, Saving Money.
  • A. Kuczynski, M. Vyas
  • Economics
    The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques
  • 2021
This is a manuscript accepted for publication in Canadian Journal of Neurological Sciences. This version may be subject to change during the production process. Investing in Endovascular Thrombectomy…
Repository Assessment of Long-term Follow-up of Randomized Trial Participants by Linkage to Routinely Collected Data : A Scoping Review and Analysis
TLDR
A scoping review of randomized clinical trials extended by record linkage to characterize this literature and explore any additional insights into treatment effectiveness provided by long-term follow-up using record linkage found some benefits of treatment extend beyond the trial, and some harms of treatment only become apparent after the trial is complete.
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