Liberating the data from clinical trials

@article{Henry2015LiberatingTD,
  title={Liberating the data from clinical trials},
  author={David Henry and Tiffany Fitzpatrick},
  journal={BMJ : British Medical Journal},
  year={2015},
  volume={351}
}
Liberated trial data have enduring potential to benefit patients, prevent harm, and correct misleading research 
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17 Citations
Background Citations
3

17 Citations

Citation Type

Citation Type

Benefits of, and barriers to, reactivating dormant trials
TLDR
The UK should follow Ontario and reactivate its treasure trove of dormant trials to generate new science through linkage with administrative data to monitor long term safety of drugs. Expand
Data sharing is desirable, but benefits should not be exaggerated
On behalf of the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) research group, we thank Henry and Fitzpatrick for their praise of how… Expand
Novel trial strategies to enhance the relevance, efficiency, effectiveness and impact of nephrology research.
TLDR
This review aims to provide an overview of strategies and approaches being utilised to improve the relevance, efficiency, effectiveness and impact of nephrology research. Expand
Assessment of Long-term Follow-up of Randomized Trial Participants by Linkage to Routinely Collected Data
TLDR
The fate of patients after participation in clinical trials is a neglected topic, and the authors recommend that researchers routinely request permission from trial participants to study long-term treatment effects using linkage to routinely collected data. Expand
Gynaecologists and industry: ain't no sunshine.
TLDR
It is suggested that specialists in the field of reproductive medicine should be transparent about the receipt of financial benefits, including funding from industry, as it may be influencing both research outcomes and treatments that patients are offered. Expand
Protocol for a scoping review of post-trial extensions of randomised controlled trials using individually linked administrative and registry data
TLDR
This scoping review aims to characterise published post-trial extension studies, assess their value, and identify any potential challenges associated with this approach, to produce guidance for investigators on the conduct of post- trial extensions using routinely collected data. Expand
Inauguration of the Journal of Emergency and Critical Care Medicine
TLDR
Emergency and critical care medicine are specialties facing life-threatening emergencies such as stroke, acute myocardial infarction, and severe trauma and most practices in emergency room and intensive care unit (ICU) lack high-level evidence. Expand
Antidepressants: Conundrums and Complexities of Efficacy Studies
  • R. Pies
  • Medicine
  • Journal of clinical psychopharmacology
  • 2016
TLDR
Despite the apparent failure of Study 329, the preponderance of research still supports modest-to-moderate efficacy—and overall safety—for several commonly used antidepressants, and influential meta-analyses suggesting that the efficacy of antidepressants for major depression is exaggerated and/or limited to severe depression. Expand
The History, Advocacy and Efficacy of Data Management Plans
TLDR
It is found that economic and societal benefits from presumed increased rates of data sharing was the original driver of mandating DMPs by funding bodies, and the view that a good DMP is necessarily that which encompasses the entire data lifecycle of a project is questioned. Expand
[Pharmacovigilance in Germany : It is about time].
TLDR
Without publicly funded large longitudinal healthcare databases and an amendment of Section 75, Book 10, of the Code of Social Law, the use of healthcare data in pharmacovigilance research in Germany will remain a rarity. Expand
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References

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The BMJ requires data sharing on request for all trials
TLDR
Heeding calls from the Institute of Medicine, WHO, and the Nordic trial Alliance, the Nordic Trial Alliance is extending its policy to include cannabis use in clinical trials across Europe. Expand
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Academics and non-commercial funders are just as guilty as industry of misleading the public about the role of science in society. Expand
Restoring invisible and abandoned trials: a call for people to publish the findings
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  • Medicine
  • BMJ : British Medical Journal
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Effectiveness of public report cards for improving the quality of cardiac care: the EFFECT study: a randomized trial.
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Effect of telehealth on use of secondary care and mortality: findings from the Whole System Demonstrator cluster randomised trial
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Telehealth is associated with lower mortality and emergency admission rates, and differences in emergency admissions were greatest at the beginning of the trial, during which the authors observed a particularly large increase for the control group. Expand
Are Routinely Collected NHS Administrative Records Suitable for Endpoint Identification in Clinical Trials? Evidence from the West of Scotland Coronary Prevention Study
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It is concluded that routinely collected data could be used for recording cardiovascular endpoints in clinical trials and would give very similar results to rigorously collected clinical trial data, in countries with unified health systems such as Scotland. Expand
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