Liarozole potentiates the all-trans-retinoic acid-induced structural remodelling in human breast carcinoma MCF-7 cells in vitro.

@article{heusden1996LiarozolePT,
  title={Liarozole potentiates the all-trans-retinoic acid-induced structural remodelling in human breast carcinoma MCF-7 cells in vitro.},
  author={J Van heusden and Marcel Borgers and Frans Ramaekers and Benoit Xhonneux and Walter Wouters and Roland De Coster and Gerda Smets},
  journal={European journal of cell biology},
  year={1996},
  volume={71 1},
  pages={89-98}
}
Liarozole inhibits cytochrome P-450-dependent enzymes that play a key role in all-trans-retinoic acid (ATRA) catabolism. In MCF-7 cells, liarozole potentiates the antiproliferative effects of ATRA. The present study demonstrates this synergistic effect on cell differentiation of MCF-7 cell cultures as measured by immunocytochemistry for cytokeratins 8, 18, and 19, actin, E-cadherin, desmoglein and desmoplakins I & II. ATRA concentration-dependently (10(-8) M-10(-6) M) induced changes in actin… CONTINUE READING
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