Li-Fraumeni syndrome with simultaneous osteosarcoma and liver cancer: Increased expression of a CD44 variant isoform after chemotherapy

@inproceedings{Yoshida2012LiFraumeniSW,
  title={Li-Fraumeni syndrome with simultaneous osteosarcoma and liver cancer: Increased expression of a CD44 variant isoform after chemotherapy},
  author={Go J Yoshida and Yasushi Fuchimoto and Tomoo Osumi and Hiroyuki Shimada and Seiichi Hosaka and Hideo Morioka and Makio Mukai and Yohei Masugi and Michiie Sakamoto and Tatsuo Kuroda},
  booktitle={BMC Cancer},
  year={2012}
}
Li-Fraumeni syndrome (LFS) is a hereditary cancer predisposition syndrome that is commonly associated with a germline mutation in the tumor suppressor gene p53. Loss of p53 results in increased expression of CD44, a cancer stem cell (CSC) marker, which is involved in the scavenging of reactive oxygen species (ROS). Here, we report a change in the expression… CONTINUE READING