Lhx2-/- mice develop liver fibrosis.

@article{Wandzioch2004Lhx2MD,
  title={Lhx2-/- mice develop liver fibrosis.},
  author={Ewa Wandzioch and Asa Kolterud and Maria Jacobsson and Scott L Friedman and Leif Carlsson},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2004},
  volume={101 47},
  pages={16549-54}
}
Liver fibrosis is a wound-healing response to chronic injury of any type and is characterized by a progressive increase in deposition of extracellular matrix (ECM) proteins, the major source of which are activated hepatic stellate cells (HSCs). Because the LIM homeobox gene Lhx2 is expressed in HSCs and liver development in Lhx2(-/-) mice is disrupted, we analyzed liver development in Lhx2(-/-) embryos in detail. Lhx2(-/-) embryos contain numerous activated HSCs and display a progressively… CONTINUE READING
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