Lgr6 marks nail stem cells and is required for digit tip regeneration.

Abstract

The tips of the digits of some mammals, including human infants and mice, are capable of complete regeneration after injury. This process is reliant on the presence of the overlaying nail organ and is mediated by a proliferative blastema. Epithelial Wnt/β-catenin signaling has been shown to be necessary for mouse digit tip regeneration. Here, we report on… (More)
DOI: 10.1073/pnas.1518874112

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