Lgr4 regulates mammary gland development and stem cell activity through the pluripotency transcription factor Sox2.

@article{Wang2013Lgr4RM,
  title={Lgr4 regulates mammary gland development and stem cell activity through the pluripotency transcription factor Sox2.},
  author={Ying Wang and Jie Dong and Dali Li and Li Lai and Stefan Siwko and Yi Li and Mingyao Liu},
  journal={Stem cells},
  year={2013},
  volume={31 9},
  pages={1921-31}
}
The key signaling networks regulating mammary stem cells are poorly defined. The leucine-rich repeat containing G protein-coupled receptor (Lgr) family has been implicated in intestinal, gastric, and epidermal stem cell functions. We investigated whether Lgr4 functions in mammary gland development and mammary stem cells. We found that Lgr4(-/-) mice had delayed ductal development, fewer terminal end buds, and decreased side-branching. Crucially, the mammary stem cell repopulation capacity was… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 37 extracted citations

LGR4 modulates breast cancer initiation, metastasis, and cancer stem cells.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology • 2018

Similar Papers

Loading similar papers…