Lgl1 Is Suppressed in Oxygen Toxicity Animal Models of Bronchopulmonary Dysplasia and Normalizes During Recovery in Air

Abstract

Bronchopulmonary dysplasia (BPD), a major cause of morbidity in premature infants, is characterized by arrest of lung growth and inhibited alveologenesis. We had earlier cloned late-gestation lung 1 (LGL1), a glucocorticoid (GC)-induced, developmentally regulated gene in lung mesenchyme, and showed that reduced levels of late-gestation lung 1 protein (lgl1… (More)
DOI: 10.1203/01.pdr.0000198819.81785.f1

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