Lgf-YL-9 induces apoptosis in human epidermoid carcinoma KB cells and multidrug resistant KBv200 cells via reactive oxygen species-independent mitochondrial pathway.

@article{Wang2007LgfYL9IA,
  title={Lgf-YL-9 induces apoptosis in human epidermoid carcinoma KB cells and multidrug resistant KBv200 cells via reactive oxygen species-independent mitochondrial pathway.},
  author={Xiao-Hong Wang and Dian-zeng Jia and Yong-ju Liang and Su-li Yan and Yan Ding and Li-ming Chen and Zhi Shi and Mu-Sheng Zeng and Guang-fei Liu and Li-wu Fu},
  journal={Cancer letters},
  year={2007},
  volume={249 2},
  pages={
          256-70
        }
}
Pyrazolon derivatives were reported to have cytotoxicity to some tumour cells. In the present study, we investigated the effect of Lgf-YL-9 on cytotoxicity and cell apoptosis in human epidermoid carcinoma drug-sensitive parental KB cells and multidrug resistant (MDR) KBv200 cells. Lgf-YL-9 exhibited potent cytotoxicity not only to KB cells but also to KBv200 cells, and the IC(50) were 3.81 and 3.45 microg/mL in KB cells and KBv200 cells, respectively. Importantly, Lgf-YL-9 effectively inhibited… CONTINUE READING

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