Leydig cell apoptosis in the rat testes after administration of the cytotoxin ethane dimethanesulphonate: role of the Bcl-2 family members.

Abstract

Ethane dimethanesulphonate (EDS) is cytotoxic to Leydig cells in the adult rat. To investigate the role and regulation of apoptosis in the Leydig cell, EDS (100 mg/kg i.p.) was administered to adult male rats and the testes examined 6, 12, 18, 24, 48 and 72 h later. Numbers of Leydig cells, identified by 3 beta-hydroxysteroid dehydrogenase immuno… (More)

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@article{Taylor1998LeydigCA, title={Leydig cell apoptosis in the rat testes after administration of the cytotoxin ethane dimethanesulphonate: role of the Bcl-2 family members.}, author={M. F. Taylor and I Woolveridge and Anthony D. Metcalfe and Charles H. Streuli and John A. Hickman and Ian D. Morris}, journal={The Journal of endocrinology}, year={1998}, volume={157 2}, pages={317-26} }