LexA-DNA bond strength by single molecule force spectroscopy.

  title={LexA-DNA bond strength by single molecule force spectroscopy.},
  author={Ferdinand K{\"u}hner and Lilian Terezinha Costa and Paulo Mascarello Bisch and Stefan Thalhammer and Wolfgang M. Heckl and Hermann Eduard Gaub},
  journal={Biophysical journal},
  volume={87 4},
The SOS system of Escherichia coli is coordinated by two proteins: LexA, a repressor protein of several unlinked genes, and the coprotease RecA. As known to date LexA controls 31 genes with slightly different DNA binding motifs allowing for a variable degree of repression from one gene to the other. Besides the SOS system LexA plays an important role in the regulation of transcription. The protein regulates transcription by using particular motifs to bind DNA, the helix-turn-helix motif. Here… CONTINUE READING


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Dynamic single-molecule force spectroscopy: bond rupture analysis with variable spacer length

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