Lewy body variant of Alzheimer's disease: alpha-synuclein in dystrophic neurites of A beta plaques.

@article{Wirths2000LewyBV,
  title={Lewy body variant of Alzheimer's disease: alpha-synuclein in dystrophic neurites of A beta plaques.},
  author={Oliver Wirths and Svenja Weickert and Katalin Majt{\'e}nyi and L{\'a}szl{\'o} Havas and Philipp J Kahle and Masayasu Okochi and Christian Haass and Gerhard Multhaup and Konrad Beyreuther and T. A. Bayer},
  journal={Neuroreport},
  year={2000},
  volume={11 17},
  pages={3737-41}
}
The contribution of alpha-synuclein accumulation in Alzheimer's disease (AD) plaques is currently a matter of scientific debate. In the present study antisera against the N- and C-terminus, the full-length protein and the central so-called non-amyloid component (NAC) domain of the alpha-synuclein protein were used to address this question in brains of cases with typical AD and of cases with the Lewy body (LB) variant of AD. In typical AD cases, none of the antisera revealed evidence for co… CONTINUE READING