Lewy body pathology involves the olfactory cells in Parkinson's disease and related disorders.

@article{Saito2016LewyBP,
  title={Lewy body pathology involves the olfactory cells in Parkinson's disease and related disorders.},
  author={Yuko Saito and Ayako Shioya and Terunori Sano and Hiroyuki Sumikura and Miho Murata and Shigeo Murayama},
  journal={Movement disorders : official journal of the Movement Disorder Society},
  year={2016},
  volume={31 1},
  pages={135-8}
}
BACKGROUND The "dual-hit" and propagation hypotheses of α-synuclein suggests that the olfactory cells of the olfactory epithelium are among the earliest sites of involvement in Parkinson's disease (PD). We investigated the olfactory epithelium in consecutive cases that had been registered with a brain bank. OBJECTIVES This study was undertaken to check the presence or absence of Lewy body pathology in olfactory cells. METHODS Thirty-six male and 11 female patients were examined, including… CONTINUE READING
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Parkinson’s disease: a dualhit hypothesis

  • CH Hawkes, K Del Tredici, H. Braak
  • Neuropathol Appl Neurobiol
  • 2007

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