Lewy body in neurodegeneration with brain iron accumulation type 1 is immunoreactive for alpha-synuclein.

@article{Arawaka1998LewyBI,
  title={Lewy body in neurodegeneration with brain iron accumulation type 1 is immunoreactive for alpha-synuclein.},
  author={Shigeki Arawaka and Yoshiaki Saito and Shigeo Murayama and Hiroshi Mori},
  journal={Neurology},
  year={1998},
  volume={51 3},
  pages={
          887-9
        }
}
In familial PD, a mutation of the alpha-synuclein gene has been identified. Alpha-synuclein also was revealed in Lewy bodies in idiopathic PD. Lewy bodies in neurodegeneration with brain iron accumulation type 1 (NBIA 1; Hallervorden-Spatz syndrome) were found to show immunostaining for alpha-synuclein/precursor of non-A beta component of Alzheimer's disease amyloid, indicating that alpha-synuclein is commonly associated with the formation of Lewy bodies in other sporadic and familial… CONTINUE READING
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