Lewy body–like pathology in long-term embryonic nigral transplants in Parkinson's disease

@article{Kordower2008LewyBP,
  title={Lewy body–like pathology in long-term embryonic nigral transplants in Parkinson's disease},
  author={Jeffrey H. Kordower and Yaping Chu and Robert A. Hauser and T. H. Freeman and Charles W. Olanow},
  journal={Nature Medicine},
  year={2008},
  volume={14},
  pages={504-506}
}
Fourteen years after transplantation into the striatum of an individual with Parkinson's disease, grafted nigral neurons were found to have Lewy body–like inclusions that stained positively for α-synuclein and ubiquitin and to have reduced immunostaining for dopamine transporter. These pathological changes suggest that Parkinson's disease is an ongoing process that can affect grafted cells in the striatum in a manner similar to host dopamine neurons in the substantia nigra. These findings have… CONTINUE READING
BETA

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-10 OF 546 CITATIONS, ESTIMATED 52% COVERAGE

1,053 Citations

050100150'10'13'16'19
Citations per Year
Semantic Scholar estimates that this publication has 1,053 citations based on the available data.

See our FAQ for additional information.

References

Publications referenced by this paper.

BR I E F COMMUNICAT IONS NATURE MEDICINE ADVANCE ONLINE PUBLICATION

  • Olanow, C.W
  • Lancet Neurol
  • 2004

Similar Papers

Loading similar papers…