Lewy bodies in progressive supranuclear palsy represent an independent disease process.

@article{Uchikado2006LewyBI,
  title={Lewy bodies in progressive supranuclear palsy represent an independent disease process.},
  author={Hirotake Uchikado and Anthony Delledonne and Zeshan Ahmed and Dennis W. Dickson},
  journal={Journal of neuropathology and experimental neurology},
  year={2006},
  volume={65 4},
  pages={
          387-95
        }
}
Progressive supranuclear palsy (PSP) is a neurodegenerative tauopathy characterized by Parkinsonism, vertical gaze palsy, and early falls. Lewy bodies (LBs) are detected in approximately 10% of PSP cases, but there is little information on the relationship of LBs to tau pathology. We determined the frequency of LBs in a large series of autopsy-confirmed cases of PSP and studied the density and distribution of LBs, including Parkinson disease stage, in cases with LBs (PSP/LBD). PSP/LBD was… CONTINUE READING
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