Lewy bodies in Alzheimer's disease: a neuropathological review of 145 cases using alpha-synuclein immunohistochemistry.

@article{Hamilton2000LewyBI,
  title={Lewy bodies in Alzheimer's disease: a neuropathological review of 145 cases using alpha-synuclein immunohistochemistry.},
  author={Ronald L. Hamilton},
  journal={Brain pathology},
  year={2000},
  volume={10 3},
  pages={
          378-84
        }
}
Antibodies to alpha-synuclein (AS) now provide a sensitive and specific method for the detection of Lewy bodies (LBs) and their use will allow a more accurate determination of the prevalence of LBs in Alzheimer's Disease (AD). Studies using AS immunohistochemistry (IHC) have found LBs in the amygdala of over 60% early onset familial AD and in 50% of Down's syndrome patients with AD, however, no studies have reported the use of AS IHC to detect LBs in a large cohort of sporadic AD. This study… CONTINUE READING
Highly Influential
This paper has highly influenced 11 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
Highly Cited
This paper has 366 citations. REVIEW CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 194 extracted citations

Ageing and Dementia Current and Future Concepts

Journal of Neural Transmission. Supplementa • 2002
View 10 Excerpts
Method Support
Highly Influenced

Current state of Alzheimer’s fluid biomarkers

Acta Neuropathologica • 2018
View 9 Excerpts
Highly Influenced

Characteristics of alpha-synucleinopathy in centenarians

Acta Neuropathologica • 2005
View 4 Excerpts
Highly Influenced

The genetic epidemiology of neurodegenerative disease.

The Journal of clinical investigation • 2005
View 5 Excerpts
Highly Influenced

366 Citations

0102030'01'04'08'12'16
Citations per Year
Semantic Scholar estimates that this publication has 366 citations based on the available data.

See our FAQ for additional information.