Lewy bodies and parkinsonism in families with parkin mutations.

  title={Lewy bodies and parkinsonism in families with parkin mutations.},
  author={Matthew J Farrer and Piu Chan and Rou-Shayn Chen and Lu Lin Tan and Sarah Lincoln and D. Hern{\'a}ndez and Lysia S. Forno and Katrina Gwinn-Hardy and Leonard Petrucelli and Jennifer Hussey and Andrew A Singleton and Caroline Tanner and John S. Hardy and James William Langston},
  journal={Annals of neurology},
  volume={50 3},
Previous work has established that compound mutations and homozygous loss of function of the parkin gene cause early-onset, autosomal recessive parkinsonism. Classically, this disease has been associated with loss of dopaminergic neurons in the substantia nigra pars compacta and locus ceruleus, without Lewy body pathology. We have sequenced the parkin gene of 38 patients with early-onset Parkinson's disease (<41 years). Two probands with mutations were followed up. Clinical evaluation of their… CONTINUE READING
Highly Influential
This paper has highly influenced 16 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS


Publications citing this paper.
Showing 1-10 of 184 extracted citations

Similar Papers

Loading similar papers…