Lewis rat pancreas, but not cardiac xenografts, are resistant to anti-gal antibody mediated hyperacute rejection.

@article{Yin2001LewisRP,
  title={Lewis rat pancreas, but not cardiac xenografts, are resistant to anti-gal antibody mediated hyperacute rejection.},
  author={Dengping Yin and Howard N. Sankary and Ling Ling Ma and Jikui Shen and Yi-yu Qin and Leonard Blinder and James Williams and Anita S Chong},
  journal={Transplantation},
  year={2001},
  volume={71 10},
  pages={1385-9}
}
BACKGROUND The objective of this study was to evaluate the role of anti-Gal Abs and non-anti-Gal Abs in hyperacute rejection (HAR) of concordant pancreas xenografts compared with heart xenografts. In addition, we tested whether rejection of Lewis rat pancreas grafts was T-cell dependent and could be prevented by anti-T-cell treatment. METHODS To determine the role of anti-Gal Abs in the induction of HAR, Lewis rat pancreas and heart xenografts were transplanted into alpha1… CONTINUE READING