Lewis-base-catalysed selective reductions of ynones with a mild hydride donor.

Abstract

Ynones are efficiently reduced with a mild hydride donor in the presence of a catalytic amount of nucleophilic phosphines. The reactions are selective 1,2-reductions that give propargyl alcohols in yields of up to 96%. It is proposed that success in these reactions depends on the activation of ynones by a Lewis base catalyst. A protic additive plays a key… (More)
DOI: 10.1039/c8cc00058a

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