Lewis acid promoted intramolecular (3 + 2) 'cycloadditions' of methyleneaziridines with alkene and alkyne acceptors.


2-Methyleneaziridines can be tethered to a variety of alkene or alkyne acceptors through the saturated carbon of the heterocyclic ring by application of a simple lithiation/alkylation sequence (8 examples, 31-59%). Treatment of the resultant alkene bearing substrates with BF(3)·OEt(2) leads to cis-octahydrocyclopenta[c]pyrroles in which up to four… (More)
DOI: 10.1039/c1ob06578e
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