Lewis Acid-Promoted Radical Carbon-Carbon Bond Forming Reactions with N-Ethylpiperidine Hypophosphite

@article{Cho2003LewisAR,
  title={Lewis Acid-Promoted Radical Carbon-Carbon Bond Forming Reactions with N-Ethylpiperidine Hypophosphite},
  author={Dae Hyan Cho and Doo Ok Jang},
  journal={Bulletin of The Korean Chemical Society},
  year={2003},
  volume={24},
  pages={15-16}
}
  • D. Cho, D. Jang
  • Published 2003
  • Chemistry
  • Bulletin of The Korean Chemical Society
Construction of carbon-carbon bonds is one of the most important tasks in organic synthesis, and the well-developed radical reactions have become important synthetic tools for forming carbon-carbon bonds of biologically important molecules. 1 In the process, organotin hydrides have played a major role. Although organotin hydrides give high yields, they have several drawbacks. Their toxicity prevents them from being used on a practical scale, and it is difficult to eliminate toxic by-products… 
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TLDR
The combination of water-soluble radical initiator 2,2'-azobis[2-imidazolin-2-yl)propane, water- soluble chain carrier 1-ethylpiperidine hypophosphite, and surfactant cetyltrimethylammonium bromide was found to be the most suitable condition for effective radical cyclization in water for a variety of hydrophobic substrates.
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