Lewis Acid Catalyzed [4 + 3] Cycloaddition of Propargylic Alcohols with Azides.

@article{Han2016LewisAC,
  title={Lewis Acid Catalyzed [4 + 3] Cycloaddition of Propargylic Alcohols with Azides.},
  author={Ya-Ping Han and Xian-Rong Song and Yi-Feng Qiu and Heng-Rui Zhang and Lian-Hua Li and Dong-Po Jin and Xiao-qing Sun and Xueyuan Liu and Yong-Min Liang},
  journal={Organic letters},
  year={2016},
  volume={18 5},
  pages={940-3}
}
An unprecedented Lewis acid catalyzed [4 + 3] cycloaddition reaction is described that provides a straightforward route to polycyclic products containing an imine-based indole azepine scaffold, starting from readily available internal tertiary alkynols and azides. This cycloaddition protocol provides efficient and atom-economical access to a new class of… CONTINUE READING