Levothyroxine Therapy in Patients with Thyroid Disease

@article{Mandel1993LevothyroxineTI,
  title={Levothyroxine Therapy in Patients with Thyroid Disease},
  author={Susan H. Mandel and G. Brent and P. Larsen},
  journal={Annals of Internal Medicine},
  year={1993},
  volume={119},
  pages={492-502}
}
Levothyroxine is one of the 13 most commonly prescribed medications in the United States, with more than 15 million prescriptions filled annually [1]. It is given as either physiologic replacement therapy in patients with hypothyroidism or as interventional therapy to suppress thyroid-stimulating hormone (TSH) secretion in patients with nodular thyroid disease or thyroid cancer. Overt hypothyroidism occurs in 1.5% to 2% of women and in 0.2% of men [2], and its incidence increases with age… Expand
223 Citations
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