Levosimendan for Ischemic Preconditioning in Thoracic Aortic Aneurysm Repair

  title={Levosimendan for Ischemic Preconditioning in Thoracic Aortic Aneurysm Repair},
  author={Ozgur Ersoy and Ali Baran Budak and Ufuk Mungan and Ufuk Tutun and Ali Parlar and Ferit Çiçekçioğlu and Ahmet Tulga Ulus and Salih Fehmi Katırcıoğlu},
  journal={Journal of Cardiac Surgery},
Abstract  Background and Aim: Postoperative neurologic deficit is the most devastating complication after surgical thoracic aorta repair. Cerebrospinal fluid drainage and some medications are used for spinal cord protection during and after the operation. Methods: A 25‐year‐old patient applied to our clinic with a traumatic descending aortic aneurysm. We performed a surgical repair for the aneurysm but could not achieve to place a lumbar catheter to provide cerebrospinal fluid drainage… 
3 Citations
Levosimendan in perioperative and critical care patients
New practice advisories and proposals for indications to treat and prevent low-output syndrome in patients at risk are warranted for patients undergoing cardiac surgery with cardiopulmonary bypass and levosimendan should also be considered as an adjunct drug for the treatment of cardiogenic shock.
Perioperative use of levosimendan: best practice in operative settings.
The active long-lived me-tabolite OR-1896, also an inodilator, shows-sensitizing effect in the cardiac myofilaments.


Risk of spinal cord dysfunction in patients undergoing thoracoabdominal aortic replacement.
A multimodality protocol appears to be effective in reducing the risk of spinal cord injury during thoracoabdominal aortic replacement.
Preconditioning effects of levosimendan in coronary artery bypass grafting--a pilot study.
Patients receiving a short infusion of levosimendan before CABG showed evidence of less myocardial damage, suggestive of a preconditioning effect, and larger outcome studies are thus indicated to confirm benefit.
Thoracoabdominal aortic aneurysms.
  • W. Edwards
  • Medicine
    The Surgical clinics of North America
  • 1982
Levosimendan, a New Inotropic and Vasodilator Agent
Levosimendan, a myofilament Ca2+ sensitizer with inotropic effects, increases myocardial performance without substantial changes in oxygen consumption and with neutral effects on heart rhythm.