Levosimendan and prostaglandin E1 for uptitration of beta-blockade in patients with refractory, advanced chronic heart failure.

@article{Berger2007LevosimendanAP,
  title={Levosimendan and prostaglandin E1 for uptitration of beta-blockade in patients with refractory, advanced chronic heart failure.},
  author={Rudolf Berger and Deddo Moertl and Martin Huelsmann and Anja Bojic and Roozbeh Ahmadi and Isabella Heissenberger and R. Pacher},
  journal={European journal of heart failure},
  year={2007},
  volume={9 2},
  pages={202-8}
}
BACKGROUND In advanced chronic heart failure (CHF) 20% of patients do not tolerate beta-blockers and 50% do not reach target doses. AIM To test whether levosimendan or prostaglandin E1 (PGE1) can facilitate uptitration of beta-blockers in advanced CHF. METHODS AND RESULTS Seventy-five advanced CHF patients (LVEF<35%, NYHA class IIIb or IV) intolerant to beta-blocker uptitration to target doses (10 mg bisoprolol/day) were randomised to a monthly 24 h infusion with levosimendan (n=39) or a… CONTINUE READING

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