Levosimendan: The current situation and new prospects.

Abstract

Levosimendan is a pyridazinone-dinitrile derivative with positive inotropic and vasodilatory effects that has beneficial effects on myocardial performance. In previous randomized studies levosimendan improved hemodynamics and clinical course, but its effect on prognosis is still unclear. This important issue has limited its use. Although primarily used in the management of acute heart failure syndromes, this new inotropic agent may play a role in other clinical conditions. This review aims to summarize current knowledge on levosimendan and to present future prospects for the use of this drug.

DOI: 10.1016/j.repc.2014.05.009

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Cite this paper

@article{Moreno2014LevosimendanTC, title={Levosimendan: The current situation and new prospects.}, author={Nuno Moreno and Marta Tavares-Silva and Andr{\'e} P Lourenço and Jos{\'e} Oliveira-Pinto and Tiago Henriques-Coelho and Adelino Ferreira Leite-Moreira}, journal={Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology}, year={2014}, volume={33 12}, pages={795-800} }