Levosimendan: from basic science to clinical practice

  title={Levosimendan: from basic science to clinical practice},
  author={J. Parissis and Pinelopi Rafouli-Stergiou and Ioannis A. Paraskevaidis and Alexandre Mebazaa},
  journal={Heart Failure Reviews},
Levosimendan is a new cardiac enhancer that exerts positive inotropic effects on the failing heart mediated by calcium sensitization of contractile proteins as well as peripheral vasodilatory effects mediated by opening of ATP-sensitive potassium channels in vascular smooth-muscle cells. Levosimendan is the most well-studied calcium sensitizer in the real clinical practice, producing greater hemodynamic and symptomatic improvement in patients with acute heart failure syndromes (AHFS) than those… CONTINUE READING
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