Levosimendan, a novel Ca2+ sensitizer, activates the glibenclamide-sensitive K+ channel in rat arterial myocytes.

@article{Yokoshiki1997LevosimendanAN,
  title={Levosimendan, a novel Ca2+ sensitizer, activates the glibenclamide-sensitive K+ channel in rat arterial myocytes.},
  author={Hisashi Yokoshiki and Yasuhiro Katsube and Masanori Sunagawa and Nick Sperelakis},
  journal={European journal of pharmacology},
  year={1997},
  volume={333 2-3},
  pages={
          249-59
        }
}
  • Hisashi Yokoshiki, Yasuhiro Katsube, +1 author Nick Sperelakis
  • Published in
    European journal of…
    1997
  • Chemistry, Medicine
  • The electrophysiological effect of levosimendan, a novel Ca(2+)-sensitizing positive inotropic agent and vasodilator, was examined on rat mesenteric arterial myocytes using the patch clamp technique. Resting potential was significantly hyperpolarized with levosimendan, with an EC50 of 2.9 microM and maximal effect (19.5 +/- 3.5 mV; n = 12) at 10 microM. Levosimendan (10 microM) significantly increased the whole-cell outward current. The currents intersected close to the calculated EK (-84 mV… CONTINUE READING

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