Levorphanol: the forgotten opioid

@article{Prommer2006LevorphanolTF,
  title={Levorphanol: the forgotten opioid},
  author={E. Prommer},
  journal={Supportive Care in Cancer},
  year={2006},
  volume={15},
  pages={259-264}
}
  • E. Prommer
  • Published 2006
  • Medicine
  • Supportive Care in Cancer
  • BackgroundLevorphanol (levo-3-hydroxy-N-methylmorphinan) is a strong opioid that is the only available opioid agonist of the morphinan series. Levorphanol was originally synthesized as a pharmacological alternative to morphine more than 40 years ago. It is considered a step-3 opioid by the World Health Organization (WHO) and has a greater potency than morphine. Analgesia produced by levorphanol is mediated via its interactions with μ, δ, and κ opioid receptors. Levorphanol is also an N-methyl-d… CONTINUE READING

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 27 REFERENCES
    Sublingual absorption of selected opioid analgesics
    • 251
    Pharmacokinetic-pharmacodynamic modeling of opioids.
    • 165
    Unidirectional analgesic cross-tolerance between morphine and levorphanol in the rat
    • 46
    Levorphanol: pharmacokinetics and steady-state plasma concentrations in patients with pain.
    • 21
    • Highly Influential
    Differential agonist regulation of the human kappa-opioid receptor.
    • 24