Levoprotiline ((−)-oxaprotiline) effects on inositol phosphate generation in human peripheral lymphocytes

@article{Schubert1991LevoprotilineE,
  title={Levoprotiline ((−)-oxaprotiline) effects on inositol phosphate generation in human peripheral lymphocytes},
  author={Timothy Schubert and Walter E. M{\"u}ller},
  journal={Journal of Neural Transmission / General Section JNT},
  year={1991},
  volume={84},
  pages={141-146}
}
The effects of the atypical antidepressant levoprotiline (LPT) on inositol phosphate metabolism were investigated in N-formyl-methionyl-leucylphenylalanine (fMLP) activated human lymphocytes. In the presence of LPT, stimulation of phosphoinositide hydrolysis by fMLP lead to an increased accumulation of inositol bisphosphates, an effect which could be detected within the range of therapeutic plasma concentrations and which is exerted by lithium in a similar way. Furthermore, incubation of… CONTINUE READING