Levonorgestrel concentrations during use of levonorgestrel rod (LNG ROD) implants.

@article{Sivin1997LevonorgestrelCD,
  title={Levonorgestrel concentrations during use of levonorgestrel rod (LNG ROD) implants.},
  author={Irving Sivin and Pekka L{\"a}hteenm{\"a}ki and Sirpa Ranta and Philip D. Darney and Cynthia Klaisle and Livia S Wan and Daniel R. Mishell and Maria Lacarra and Osborne A C Viegas and P Bilhareus and Suporn Koetsawang and Manee Piya-Anant and Soledad D{\'i}az and Margarita Pavez and Francisco {\'A}lvarez and Vivian Brache and Katherine D. Laguardia and Harold A. Nash and Jennifer C. Stern},
  journal={Contraception},
  year={1997},
  volume={55 2},
  pages={
          81-5
        }
}
In a three-year randomized trial that included 398 women, blood samples were collected for the purpose of assaying levonorgestrel concentrations in women using a new two-rod contraceptive implant system or an earlier implant formulation, Norplant-2 implants. Sample collection was at 1, 3, 6, 9, and 12 months after placement and semiannually thereafter through three years. Resulting assays and analyses showed that levonorgestrel concentrations of each implant formulation decreased significantly… CONTINUE READING

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