Levomilnacipran (Fetzima)

@article{Saraceni2014Levomilnacipran,
  title={Levomilnacipran (Fetzima)},
  author={Megan M Saraceni and Jineane V. Venci and Mona A Gandhi},
  journal={Journal of Pharmacy Practice},
  year={2014},
  volume={27},
  pages={389 - 395}
}
In July 2013, the US Food and Drug Administration approved levomilnacipran extended release (ER; Fetzima), a serotonin-norepinephrine reuptake inhibitor, for the treatment of adults with major depressive disorder. Levomilnacipran is an active enantiomer of the racemic drug milnacipran that is currently approved in the United States for the treatment of fibromyalgia. This article provides an overview of the mechanism of action, pharmacokinetic properties, clinical efficacy, safety, and… 
6 Citations
Levomilnacipran Extended-Release: A Review of Its Use in Adult Patients with Major Depressive Disorder
  • L. Scott
  • Psychology, Medicine
    CNS Drugs
  • 2014
TLDR
Oral levomilnacipran extended-release ER was an effective and generally well-tolerated treatment in adults with MDD participating in 8-week phase III trials and a 1-year extension study and the efficacy was maintained during the extension study, with no new safety signals detected.
Assessment of Antidepressant Effect of the Aerial Parts of Micromeria myrtifolia Boiss. & Hohen on Mice
TLDR
The present research confirmed the antidepressant’s potential of Micromeria myrtifolia Boiss by evaluating the antidepressant activity of the extracts evaluated by using several in vivo and in vitro experimental models of depression.
Novel and Investigational Drugs in Depression
TLDR
This article will highlight new psychopharmacological agents and investigational directions which may show promise in achieving better outcomes and symptom relief for those suffering from depression.
Characterization of a conglomerate-forming derivative of (±)-milnacipran and its enantiomeric resolution by preferential crystallization
Among some derivatives of milnacipran, a last-generation antidepressive drug with useful application in the treatment of fibromyalgia, N-isobutyramide (±)-4 was identified as a conglomerate-forming
Antidepressant-like effects and mechanisms of flavonoids and related analogues.
TLDR
This review article focuses on the antidepressant-like effect, structure-activity relationship and mechanism of action of total flavonoids extracts isolation from natural sources, flavonoid compounds and their related analogues.

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