Levofloxacin-Induced Acute Fulminant Hepatic Failure in a Patient with Chronic Hepatitis B Infection

@article{oban2005LevofloxacinInducedAF,
  title={Levofloxacin-Induced Acute Fulminant Hepatic Failure in a Patient with Chronic Hepatitis B Infection},
  author={Şahin Çoban and Bilge Ceydilek and Fuat Ekız and Esra Erden and Irfan Soykan},
  journal={Annals of Pharmacotherapy},
  year={2005},
  volume={39},
  pages={1737 - 1740}
}
OBJECTIVE: To report a case of possible levofloxacin-induced acute fulminant hepatic failure. CASE SUMMARY: An unconscious 55-year-old woman was hospitalized with the diagnosis of hepatic encephalopathy. The patient had received levofloxacin 500 mg daily for 10 days because of an upper respiratory infection. Her past medical history revealed hepatitis B surface antigen positivity as an asymptomatic hepatitis B virus carrier for 10 years. After hospitalization, treatment included plasmapheresis… 

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References

SHOWING 1-10 OF 23 REFERENCES
Fatal subfulminant hepatic failure with ofloxacin
TLDR
An intense inflammatory response consisting of lymphocytes, polymorphonuclear cells, and some eosinophils, with a panlobe distribution and a significant increase of the portal zone with a bridging necrosis is reported, causing a fatal subfulminant hepatic failure secondary to ofloxacin administration.
Gatifloxacin‐Associated Acute Hepatitis
TLDR
Clinicians should be alerted to the possibility that hepatitis may occur with gatifloxacin administration because of concerns about the use of certain fluoroquinolones because of adverse drug reactions.
Evaluation of the therapeutic effect of pefloxacin in comparison with ampicillin and gentamicin in cirrhotic patients with spontaneous bacterial peritonitis.
TLDR
Considering the benefits of oral treatment and the low incidence of side effects of pefloxacin it is concluded that this regimen should be the treatment of choice for SBP patients, especially when there is a shortage of hospital beds.
Use of Fluoroquinolones in Patients with Chronic Hepatitis C Virus-Induced Liver Failure
TLDR
The role of fluoroquinolones as antiviral agents for chronic HCV in patients with advanced liver disease appears to be limited, as serum HCV-RNA levels and liver enzyme abnormalities remained largely unchanged.
Acute hepatitis associated with oral levofloxacin therapy in a hemodialysis patient.
  • J. Schwalm, Christine H. Lee
  • Medicine, Biology
    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne
  • 2003
TLDR
A case of levofloxacin-associated severe hepatocellular injury is presented and it is shown that the hepatitis resolved soon after discontinuation of levoquinolone.
Possible levofloxacin-induced acute hepatocellular injury in a patient with chronic obstructive lung disease.
TLDR
A case of severe acute liver toxicity that apparently complicated intravenous administration of levofloxacin is reported, which resolved after discontinuation of the drug.
Treatment of chronic hepatitis C with alpha-interferon plus ofloxacin in patients not responding to alpha-interferon alone.
TLDR
The combined administration of alpha-interferon and ofloxacin to patients with chronic hepatitis C who have not responded to alpha- interferon alone does not increase the primary virological response rate.
Incidence of and risk factors for severe hepatotoxicity associated with antiretroviral combination therapy.
TLDR
Patients with human immunodeficiency virus (HIV) type 1 infection who are starting to receive highly active antiretroviral therapy (HAART) and HBV-coinfected patients using 3TC should be considered, even if 3TC-resistant HIV strains develop.
Drug points: Quinolones may induce hepatitis
TLDR
A 21 year old man with Wegener's granulomatosis developed jaundice after a five day course of ofloxacin (Tarivid) and two doses of ciprofloxacins prescribed for a productive cough.
...
1
2
3
...