Levodropropizine reduces capsaicin- and substance P-induced plasma extravasation in the rat trachea.

  title={Levodropropizine reduces capsaicin- and substance P-induced plasma extravasation in the rat trachea.},
  author={Isao Yamawaki and Pierangelo Geppetti and Claude P. Bertrand and O Huber and Luisa Daffonchio and Claudio Omini and Jay A. Nadel},
  journal={European journal of pharmacology},
  volume={243 1},
We investigated the effect of the non-opioid, peripherally acting antitussive agent levodropropizine to reduce neurogenic plasma extravasation in the rat trachea. Levodropropizine (10, 50 and 200 mg/kg) reduced in a dose-dependent manner the extravasation of Evans blue dye evoked by capsaicin. Levodropropizine inhibited also substance P-evoked extravasation, whereas it did not affect the extravasation evoked by platelet activating factor. Levodropropizine (10 and 100 microM) did not affect the… 
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