Levodopa treatment and dendritic spine pathology

  title={Levodopa treatment and dendritic spine pathology},
  author={Haruo Nishijima and Tatsuya Ueno and Yukihisa Funamizu and Shinya Ueno and Masahiko Tomiyama},
  booktitle={Movement disorders : official journal of the Movement Disorder Society},
Parkinson's disease (PD) is a neurodegenerative disorder associated with the progressive loss of nigrostriatal dopaminergic neurons. Levodopa is the most effective treatment for the motor symptoms of PD. However, chronic oral levodopa treatment can lead to various motor and nonmotor complications because of nonphysiological pulsatile dopaminergic stimulation in the brain. Examinations of autopsy cases with PD have revealed a decreased number of dendritic spines of striatal neurons. Animal… CONTINUE READING