Levodopa response motor complications--GABA receptors and preproenkephalin expression in human brain.

@article{Calon2002LevodopaRM,
  title={Levodopa response motor complications--GABA receptors and preproenkephalin expression in human brain.},
  author={Fr{\'e}d{\'e}ric Calon and Th{\'e}r{\`e}se Di Paolo},
  journal={Parkinsonism & related disorders},
  year={2002},
  volume={8 6},
  pages={449-54}
}
Post-mortem studies in human brain of patients with Parkinson's disease have greatly contributed to our understanding of the disease. However, few human brain studies have focused on levodopa-induced dyskinesias, which considerably limit the beneficial effect of levodopa (LD) in the treatment of Parkinson's disease. We have taken advantage of the fact that some patients develop dyskinesias and other do not to compare biochemical markers between them. In post-mortem samples from LD-treated… CONTINUE READING
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