Levodopa-related wearing-off in Parkinson's disease: identification and management

@article{Pahwa2009LevodoparelatedWI,
  title={Levodopa-related wearing-off in Parkinson's disease: identification and management},
  author={Rajesh Pahwa and Kelly E. Lyons},
  journal={Current Medical Research and Opinion},
  year={2009},
  volume={25},
  pages={841 - 849}
}
  • R. Pahwa, K. Lyons
  • Published 19 February 2009
  • Medicine
  • Current Medical Research and Opinion
ABSTRACT Background: Levodopa is currently the most effective treatment for Parkinson's disease (PD); however, long-term levodopa therapy often results in motor complications, such as motor fluctuations and dyskinesia. The initial complication is commonly wearing-off, which is the re-emergence of motor and non-motor symptoms before the next scheduled levodopa dose. Objective: The purpose of this article was to review published literature that discusses wearing-off, focusing on the role of the… 
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