Levodopa pharmacokinetics and dyskinesias: are there sex-related differences?


We examined the potential sex-related differences in levodopa pharmacokinetics and their relation with the presence of dyskinesias in a group of 115 patients (67 men, 49 women) with Parkinson’s disease. The patients were given a standard oral dose of levodopa plus benserazide (100/25 mg). The area under the levodopa plasma concentration time curve, corrected for the levodopa test dose (in mg/kg body weight), (AUCw) was significantly higher in women than in men, with a reduced oral clearance. No difference in the proportion of men and women experiencing dyskinesias was observed.

DOI: 10.1007/s10072-003-0125-z

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@article{Martinelli2003LevodopaPA, title={Levodopa pharmacokinetics and dyskinesias: are there sex-related differences?}, author={Paolo Martinelli and Manuela Contin and Cristina Scaglione and Roberta Riva and Fiorenzo Albani and Agostino Baruzzi}, journal={Neurological Sciences}, year={2003}, volume={24}, pages={192-193} }