Levodopa induces apoptosis in cultured neuronal cells--a possible accelerator of nigrostriatal degeneration in Parkinson's disease?

@article{Ziv1997LevodopaIA,
  title={Levodopa induces apoptosis in cultured neuronal cells--a possible accelerator of nigrostriatal degeneration in Parkinson's disease?},
  author={Ilan Ziv and Rina Zilkha-Falb and Daniel Offen and Anat Shirvan and Ari Barzilai and Eldad Melamed},
  journal={Movement disorders : official journal of the Movement Disorder Society},
  year={1997},
  volume={12 1},
  pages={
          17-23
        }
}
Apoptosis is an active, intrinsic cell suicide program. We recently suggested that it may have a role in the death of nigrostriatal dopaminergic neurons in Parkinson's disease (PD). We now report that levodopa, the current major therapy for PD, is a potent inducer of apoptosis in cultured postmitotic chick sympathetic neurons. Levodopa, in a concentration range of 0.01-0.3 mM, caused the characteristic apoptotic cascade of cell shrinkage, massive membrane blebbing, and nuclear fragmentation, as… CONTINUE READING
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