Levodopa induces a cytoplasmic localization of D1 dopamine receptors in striatal neurons in Parkinson's disease.

@article{Muriel1999LevodopaIA,
  title={Levodopa induces a cytoplasmic localization of D1 dopamine receptors in striatal neurons in Parkinson's disease.},
  author={M P Muriel and V{\'e}ronique Bernard and Allan I. Levey and Ouahiba Laribi and Djoher Nora Abrous and Yves Agid and Bertrand Bloch and Etienne C. Hirsch},
  journal={Annals of neurology},
  year={1999},
  volume={46 1},
  pages={103-11}
}
Parkinson's disease is characterized by a massive loss of nigral dopamine neurons that results in a reduction of dopamine concentrations in the striatum. The most commonly used treatment for this disease is levodopa therapy to restore striatal dopamine. This treatment is mediated by dopamine receptors, but the effect of treatment and the disease on receptor distribution is unknown. In this study, the distribution of D1 dopamine receptors was analyzed at the cellular and subcellular level in the… CONTINUE READING

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