Levodopa-induced plasticity: a double-edged sword in Parkinson's disease?

@article{Calabresi2015LevodopainducedPA,
  title={Levodopa-induced plasticity: a double-edged sword in Parkinson's disease?},
  author={Paolo Calabresi and Veronica Ghiglieri and Petra Mazzocchetti and I Corbelli and Barbara Picconi},
  journal={Philosophical transactions of the Royal Society of London. Series B, Biological sciences},
  year={2015},
  volume={370 1672}
}
The long-term replacement therapy with the dopamine (DA) precursor 3,4-dihydroxy-l-phenylalanine (L-DOPA) is a milestone in the treatment of Parkinson's disease (PD). Although this drug precursor can be metabolized into the active neurotransmitter DA throughout the brain, its therapeutic benefit is due to restoring extracellular DA levels within the dorsal striatum, which lacks endogenous DA as a consequence of the neurodegenerative process induced by the disease. In the early phases of PD, L… CONTINUE READING
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