Levodopa increases memory encoding and dopamine release in the striatum in the elderly

@article{Floel2008LevodopaIM,
  title={Levodopa increases memory encoding and dopamine release in the striatum in the elderly},
  author={Agnes Floel and Gaetan Garraux and Benke Xu and Caterina Breitenstein and Leonardo G. Cohen},
  journal={Neurobiology of Aging},
  year={2008},
  volume={29},
  pages={267-279}
}
Normal aging is associated with a decrease in dopaminergic function and a reduced ability to form new motor memories with training. This study examined the link between both phenomena. We hypothesized that levodopa would (a) ameliorate aging-dependent deficits in motor memory formation, and (b) increase dopamine availability at the dopamine type 2-like (D2) receptor during training in task-relevant brain structures. The effects of training plus levodopa (100mg, plus 25mg carbidopa) on motor… CONTINUE READING

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